FIGURE 1.

Surgical metastasectomy within the Surgery Branch, NCI from July 2002 to 2007. Every tumor was recorded and exclusions criteria were applied as described. Each remaining specimen was processed for fragment-derived cultures, digest-derived cultures, or both. A tumor was considered positive for growth if at least 1 fragment-derived or digest-derived culture met criteria (fragment 313, digest 35, both 329). Similarly, a tumor was considered active based on interferon-γ enzyme-linked immunosorbent assay as described (fragment 210, digest 50, both 162). Of the 107 patients treated, 63 were treated with cells derived from fragments only, 10 from digests only, and 34 from a mixture of digest-derived and fragment-derived tumor infiltrating lymphocyte.