Fig 5. The LHF-535-resistant Tacaribe virus variant F425L is attenuated in AG129 mice and protects against subsequent challenge with the virulent wild-type virus.

(A) LD₅₀ study with F425L (n = 6 per group). (B) LD₅₀ study with Tacaribe virus (n = 6 per group). (C) Mice (n = 5) infected with F425L (2,000 PFU) were challenged 31 days later with wild-type Tacaribe virus (200 PFU). Age-matched naïve mice (n = 6) were infected with wild-type Tacaribe virus (200 PFU) as a control.