Table 4. LHF-535 sensitivity and pathogenicity of variants.
| Isolate | IC50 (μM) | In vivo LD50 |
|---|---|---|
| Wild type | 0.001 | < 2 PFU |
| A144V, V421A | > 0.1 | < 2 PFU |
| F425L | > 5 | > 2000 PFU |
| T434I | > 1 | > 2000 PFU |
| F436L | > 5 | > 2000 PFU |
| F436I | 0.2 | > 2000 PFU |
| A144V, C424G | 0.05 | 6 PFU |
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