Table 2.

Types of collagen identified and the number of peptides significantly up- and down-regulated

Collagen types	No. of peptidesa	-Fold change		p valuec	-Fold changed
		>0b	<0b
P02452 (COL01A1)	286	239	11	1.84 × 10−09	1.7
P08123 (COL01A2)	189	158	10	9.4 × 10−10	1.7
P02458 (COL02A1)	5	1	0	2.4 × 10−03	1.2
P02461 (COL03A1)	210	135	16	7.6 × 10−06	1.5
P02462 (COL04A1)	33	24	3	7.0 × 10−07	1.5
P08572 (COL04A2)	33	30	0	2.92 × 10−12	2.0
P53420 (COL04A4)e	1	1	0	5.19 × 10−06	1.9
P20908 (COL05A1)	31	30	0	3.15 × 10−14	2.0
P05997 (COL05A2)	50	49	1	7.73 × 10−16	2.3
P25940 (COL05A3)e	1	1	0	6.2 × 10−04	1.6
P12109 (COL06A1)	35	10	4	2.8 × 10−02	1.2
P12110 (COL06A2)	30	8	1	1.7 × 10−03	1.3
P12111 (COL06A3)	96	39	2	6.5 × 10−04	1.3
Q02388 (COL07A1)	2	2	0	9.7 × 10−11	2.2
P27658 (COL08A1)e	1	0	1	1.1 × 10−02	0.7
Q03692 (COL10A1)	7	6	0	2.3 × 10−08	1.7
P12107 (COL11A1)	5	4	0	3.5 × 10−14	2.0
Q99715 (COL12A1)	58	50	2	6.9 × 10−14	2.0
Q05707 (COL14A1)	46	29	3	8.8 × 10−07	1.5
P39059 (COL15A1)	2	2	0	7.1 × 10−08	1.8
Q07092 (COL16A1)	2	1	0	6.7 × 10−01	1.0
P39060 (COL18A1)	14	1	1	6.2 × 10−01	1.0

^a The number of peptides identified per collagen-α chain.

^b The number of peptides with a -fold change >0 or <0 and p < 0.05. The -fold change is based on log₁₀ values.

^c Indicates the p value at the protein level.

^d Indicates the true -fold change at the protein level (not the log₁₀ value).

^e These proteins are identified with one peptide, and their identification is considered as less reliable compared with proteins identified with two or more peptides.