Figure 3.

POOL results show distal sites are important for biochemical function. POOL analysis performed on an ensemble of caspase-6 crystal structures in various activation states and conformations indicated by PDB codes in the figure. The top 12% of residues identified and predicted to be important for enzymatic function for each structure are highlighted in gray. Residues further clustered based on their conformational state: helical or strand, as well as their proximity to the caspase-6 active-site, 130's region, or distal positions.