Figure 1.

Strand-specific excision repair of rDNA transcribed by RNA polymerase I and DHFR transcribed by RNA polymerase II in various genetic backgrounds. A, screenshots showing quantitative XR-seq repair reads from a representative experiment. Top, rDNA (RNA45SN5, NR_046235.3); bottom, DHFR. B, quantitative analysis of rDNA and DHFR XR-seq repair from two experiments. NS, not significant; **, p < 0.01, Student's t test. C, frequency of the relevant dinucleotide, T-T, at each position of the 26-nt XR-seq excision fragments mapped to rDNA (RNA45SN5) and DHFR for different cell lines, respectively.