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. 2018 Nov 8;294(1):195–209. doi: 10.1074/jbc.RA118.004086

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© 2019 Hirota et al.

Published under exclusive license by The American Society for Biochemistry and Molecular Biology, Inc.

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Figure 4. — Microarray analysis of CHD4- and MBD3-dependent genes during neural differentiation of ESCs. A, unsupervised hierarchical cluster analysis of gene expression profiles. B, heatmap for the 1329 genes whose expression was up-regulated by more than 2-fold during neural differentiation (left). Venn diagrams of 1329 genes (right, upper). The magenta and yellow circles represent CHD4- and MBD3-dependent up-regulated genes, respectively. GO analysis of CHD4- and MBD3-dependent up-regulated genes (right, lower). C, heatmap for the 805 genes whose expression was down-regulated less than half during neural differentiation (left). Venn diagrams of 805 genes (right, upper). The magenta and yellow circles represent CHD4- and MBD3-dependent down-regulated genes, respectively. GO analysis of CHD4- and MBD3-dependent down-regulated genes (right, lower).