Figure 2. Groups of diffuse gliomas classified according to IDH mutation and 1p/19q codeletion status demonstrate a distinct landscape of molecular features.

Gene pathways are indicated. Genes in orange indicate genes preferentially targeted by gain-of-function (such as hotspot) mutational events or amplification events. Genes marked in blue indicate genes commonly affected by loss-of-function mutation (such as frameshift) or deletion events. Only features with frequencies greater than five percent are shown. Frequencies were derived from a recent publication¹¹³. TPM = TERT promoter mutation, RTK = receptor tyrosine kinase, PI3K = phosphoinositide-3 kinase, TMM = telomere maintenance mechanism.