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. Author manuscript; available in PMC: 2020 Jan 8.
Published in final edited form as: Biochem Biophys Res Commun. 2018 Dec 3;508(2):614–619. doi: 10.1016/j.bbrc.2018.11.125

Figure 2. Platelet TLR4/NLRP3 signaling promotes platelet aggregation in FAL.

Figure 2.

(A) Collagen-induced platelet aggregation is increased when WT mice are subjected to FAL and decreased in NLRP3−/− mice. (B) Collagen-induced platelet aggregation is increased when TLR4 Flox control mice mice are subjected to FAL and decreased in TLR4 PF4 mice. (C) Downregulated platelet aggregation in TLR4 PF4 mice is restored by the NLRP3 activator Nigericin, which does not occur in platelets derived from TLR4 Flox controls. Data are presented as mean ± SD for N≥3 and at least three separate experiments in all studies. **p < 0.01, ***p < 0.001 (2-way ANOVA with Bonferroni post-hoc test in A-C).