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. Author manuscript; available in PMC: 2020 Jan 8.
Published in final edited form as: Biochem Biophys Res Commun. 2018 Dec 3;508(2):614–619. doi: 10.1016/j.bbrc.2018.11.125

Figure 3. Absence of platelet TLR4 and NLRP3 improves perfusion recovery two weeks after FAL.

Figure 3.

(A) Perfusion of the femoral artery subjected to ligation and that of the contralateral nonligated femoral artery is evaluated by LDPI in TLR4 Flox, TLR4 PF4, WT (C57BL/6), and NLRP3−/− mice at baseline (day 0), shortly after FAL induction (day 1), and on days 7 and 14. (B) Two weeks after the induction of FAL, the ischemia/nonischemia perfusion ratio is increased in TLR4 PF4 mice as compared with that in TLR4 Flox control mice. (C) Two weeks after the induction of FAL, the ischemia/nonischemia perfusion ratio is increased in NLRP3−/− mice as compared with that in WT (C57BL/6) control mice. Data are presented as mean ± SD for N≥3 and at least three separate experiments in all studies. *p < 0.05, ***p < 0.001 (2-way ANOVA with Bonferroni post-hoc test in B, C).