(A) Average contacts between the central villin and crowder molecules as a function of spherical radii based on heavy-atom distances of less than 0.27 nm (red), 0.57 nm (blue), and 0.87 nm (green). (B) Cluster size distributions involving the central villin molecule for different spherical radii (0.0 – blue, 1.8 – red, 2.0 – green, 2.2 – orange, 2.4 – pink, 2.6 – yellow, 2.8 – purple). Error bars were obtained from block averaging.