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. Author manuscript; available in PMC: 2020 Jan 1.
Published in final edited form as: J Thromb Haemost. 2018 Dec 16;17(1):149–156. doi: 10.1111/jth.14337

Figure 2. PZ or ZPI deletion reduces bleeding in hemophilia mice.

Figure 2.

A. Effects of PZ or ZPI gene-deletion in hemophilia mice on the TVRB. The number of clot disruptions in 15 min. are shown. All comparisons are significantly different (p<0.001) except that between the PZKO/FVIIIKO and ZPIKO/FVIIIKO animals. B. Effects of PZ or ZPI gene-deletion in FVIIIKO mice on thrombin generation. Shown are mouse TF-induced thrombin generation assays for PZKO/FVIIIKO mouse plasma (red), ZPIKO/FVIIIKO mouse plasma (blue), and WT/FVIIIKO mouse plasma supplemented with rFVIII to 0% (dotted line), 6% (light gray), 13% (dark gray), or 25% (black). The inset shows the endogenous thrombin potential (ETP) for the TGA assays; PZKO/FVIIIKO mouse plasma (red solid circle), ZPIKO/FVIIIKO mouse plasma (blue solid circle) and WT/FVIIIKO plasma supplemented with rFVIII where 1 U/mL = 100% FVIII.