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. Author manuscript; available in PMC: 2020 Jan 1.
Published in final edited form as: J Thromb Haemost. 2018 Dec 16;17(1):149–156. doi: 10.1111/jth.14337

Figure 3. PZ inhibition enhances thrombin generation in human hemophilia plasma.

Figure 3.

A. Effects of the anti-PZ Mab (2506.B12.1) on PZ-dependent, ZPI inhibition of FXa in a system using purified components. B. Effects of the anti-PZ Mab on pooled human hemophilic plasma thrombin generation. Shown are human TF-induced thrombin generation assays for pooled (n=4) human hemophilia plasma supplemented without (dotted line) or with anti-PZ Mab at 0.125 mg/mL (light red), 0.5 mg/mL (red) or 2.0 mg/mL (dark red) or with rFVIII at 3% (light gray), 6% (gray), 13% (dark gray) or 25% (black). The inset shows the ETP for the anti-PZ TGA data (gray circles) and FVIII replacement TGA data for supplementation with up to 200% rFVIII [1 U/mL=100% (black circles)]. C. Effects of anti-PZ Mab on TF-induced thrombin generation in the four individual human hemophilia plasmas: without (dotted lines) or with 2 mg/mL anti-PZ Mab (solid lines).