. 2018 Nov 25;86(1):75–87. doi: 10.1002/mrd.23082

Table 2.

Metabolites reported to affect preimplantation development present in uterine horn ipsilateral to the side of ovulation within the first 7 days relative to ovulation

Mode	Mass	Time	Putative identification	Action on preimplantation development (species)
(−)	152.0	0.80	3‐Sulfino‐l‐alanine	Increase development to blastocyst stage (rats) ^a
(−)	215.0	0.71	Glucose/fructose	Phosphorylates mTORC1 and ribosomal S6 kinase ^a (rabbit) ^b ; increased reactive oxygen species (mouse) ^c
(−)	217.0	0.71	Glucose/fructose	Phosphorylates mTORC1 and ribosomal S6 kinase ^a (rabbit) ^b ; increased reactive oxygen species (mouse) ^c
(−)	133.0	1.04	Malate	Improve development to 8‐cell stage (hamster) ^d
(−)	133.0	1.19	Malate	Improve development to 8‐cell stage (hamster) ^d
(−)	116.0	1.16	N‐Acetylglycine	Increase development to blastocyst stage (rats) ^a
(−)	116.0	1.16	N‐Acetylglycine	Increase development to blastocyst stage (rats) ^a
(−)	160.1	0.89	N‐Methyl‐l‐glutamate	Increase development to blastocyst stage (rats) ^a
(−)	124.0	0.71	Taurine	Increased embryo viability (bovine) ^e ; increase development to blastocyst stage (rats) ^a
(+)	157.0	0.98	(R)‐Malate	Improve development to 8‐cell stage (hamster) ^d
(+)	132.1	0.77	5‐Aminolevulinic acid	Impaired development to the blastocyst stage (mouse) ^f
(+)	137.0	6.07	Allopurinol	Inhibits morula and blastocyst formation (rabbit) ^g
(+)	391.3	16.57	Bis(2‐ethylhexyl) phthalate	Impaired development to the blastocyst stage (mouse) ^h
(+)	279.2	14.66	Dibutyl phthalate	Impaired development to the blastocyst stage (mouse) ^h
(+)	162.1	0.94	l‐Carnitine	Decrease size of lipid bodies (mice) ⁱ ; increased rate of ATP:ADP conversion (bovine) ^j
(+)	132.1	2.51	Leucine	Altered gene expression in mTORC dependent manner (rabbit) ^b
(+)	132.1	2.24	Leucine	Regulated TE motility (mouse) ^k
(+)	150.1	1.62	l‐Methionine	Increase lipid accumulation and reduces methylation (bovine) ^l
(+)	223.1	12.40	Monobutyl phthalate	Impaired development to the blastocyst stage (mouse) ^h
(+)	126.0	0.71	Taurine	Increased embryo viability (bovine) ^e ; increase development to blastocyst stage (rats) ^a

^{^a}

Nakamura et al. (2016).

^{^b}

Gürke et al. (2016).

^{^c}

Nasr‐Esfahani and Johnson (1991).

^{^d}

Ain and Seshagiri (1997).

^{^e}

Ealy et al. (1992).

^{^f}

Yang, Greer, Van Vugt, and Reid (1995).

^{^g}

Miyazaki, Kuo, Dharmarajan, Atlas, and Wallach (1989).

^{^h}

Chu et al. (2013).

^ⁱ

Kyvelidou et al. (2016).

^{^j}

Sutton‐McDowall, Feil, Robker, Thompson, and Dunning (2012).

^{^k}

González et al. (2012).

^{^l}

Acosta et al. (2016).