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. Author manuscript; available in PMC: 2019 Dec 15.
Published in final edited form as: Bioorg Med Chem. 2018 Nov 10;26(23-24):6067–6075. doi: 10.1016/j.bmc.2018.11.012

Figure 6. LCL521 has predominant action on decrease of P-ACDase expression and Sph formation.

Figure 6.

A. Cells were pretreated with either vehicle or 40uM CHX 1h before vehicle, 10μM LCL521, or in combination with 10 μM LCL521 for 1, 8 and 24h. ACDase protein expression (α-and P-ACDase) was then visualized by western blot as described; actin was utilized to monitor protein loading and transfer. B. Matched SL-profile, which are presented as means ± st dev. of triplicates, * p value <0.005; ** p value <0.05 (vs Control).