Table 3.

Clinical characteristics of the study cases by mutation status

	CDH1 mutation positive		CDH1 mutation negative		p value
	n	%	n	%
Total	17	18	77	82
Gender
Male	7	14	43	86
Female	10	23	34	77	0.296
Age at diagnosis (years)
< 45	14	67	7	33
45–59	2	6	30	94
60–74	1	3	29	97
> 75	0	0	11	100	< 0.001
Tumour subtype
Diffuse	17	34	33	66
Intestinal	0	0	22	100
Other	0	0	9	100
NOS	0	0	13	100	< 0.001
Tumour grade
Well differentiated	0	0	4	100
Moderately differentiated	0	0	10	100
Poorly differentiated	3	6	44	94
NOS	14	42	19	58	< 0.001
Tumour site
Proximal	4	13	26	87
Distal	1	5	19	95
Mixed	0	0	4	100
Oesophageal junction	0	0	5	100
NOS	12	34	23	66	0.048
Extent
Local	15	58	11	42
Lymph node involvement	0	0	20	100
Regional spread	0	0	7	100
Metastatic spread	2	15	11	85
NOS	0	0	28	100	< 0.001

NOS not otherwise specified