Table 1.
Effects of Rk1 on body weight, organ indices, and serum biochemical markers in mice
| Groups | Dosage (mg/kg) | Body weight (g) |
Liver index (mg/g, ×100) | Spleen index (mg/g, ×100) | ALT (U/L) | AST (U/L) | |
|---|---|---|---|---|---|---|---|
| Initial | Final | ||||||
| Normal | — | 29.74 ± 1.16 | 33.23 ± 1.16 | 5.69 ± 0.39 | 0.46 ± 0.04 | 23.85 ± 3.86 | 10.69 ± 4.16 |
| APAP | — | 29.97 ± 1.25 | 27.07 ± 1.18* | 6.50 ± 0.52** | 0.58 ± 0.06** | 114.03 ± 5.90** | 64.87 ± 13.18** |
| APAP + Rk1 | 10 | 29.68 ± 1.43 | 31.29 ± 1.34# | 5.70 ± 0.37## | 0.47 ± 0.03## | 28.32 ± 8.63## | 21.73 ± 5.24## |
| APAP + Rk1 | 20 | 29.71 ± 1.49 | 30.45 ± 1.62 | 5.89 ± 0.36# | 0.49 ± 0.07# | 31.80 ± 7.64## | 24.05 ± 8.19## |
Values represent the mean ± standard deviation, n = 8
*p < 0.05 versus normal group; **p < 0.01; #p < 0.05 versus APAP group; ##p< 0.01
ALT, alanine aminotransferase, APAP, paracetamol; AST, aspartate aminotransferase