Table 2.
Pathological changes in the liver and ridit analysis
| Groups | Dosage (mg/kg) | Necrocytosis grade |
Score | Ridit analysis | |||||
|---|---|---|---|---|---|---|---|---|---|
| n | 0 | 1 | 2 | 3 | 4 | ||||
| Normal | — | 8 | 8 | 0 | 0 | 0 | 0 | 0 | 0.21 |
| APAP | — | 7 | 0 | 0 | 2 | 3 | 2 | 21 | 0.84** |
| APAP+Rk1 | 10 | 8 | 3 | 2 | 2 | 1 | 0 | 9 | 0.48# |
| APAP+Rk1 | 20 | 8 | 2 | 3 | 2 | 1 | 0 | 10 | 0.52# |
Necrocytosis was classified based on hematoxylin–eosin staining of liver sections. Data were analyzed by ridit analysis. Values represent the mean ± standard deviation
**p < 0.01 versus normal group; #p < 0.05 versus APAP group
Grading standard: level 0, no necrocytosis, normal liver cells; level 1, liver cells contain necrocytosis of no more than 1/4; level 2, liver cells contain necrocytosis of no more than 1/2; level 3, liver cells contain necrocytosis of no more than 3/4; level 4, liver tissue was almost all necrocytosis. Level 0 calculated 0 marks; Level I calculated 1 mark; Level II calculated 2 marks; Level III calculated 3 marks; Level IV calculated 4 marks. APAP, paracetamol.