Table 3.
Optimization of biodegradable zinc pectinate beads using 23 full factorial design.
| Formulation code | Factors |
Responses |
|||
|---|---|---|---|---|---|
| X1 | X2 | X3 | Y1 | Y2 | |
| Pectin concentration % (w/v) | Zinc acetate concentration % (w/v) | Pterostilbene:pectin ratio | EE (%) Mean ± SD (n = 3) |
In vitro drug release till 24 h (%) Mean ± SD (n = 3) |
|
| F1 | 2.00 | 1.00 | 1:4 | 71.37 ± 2.27 | 96.48 ± 4.86 |
| F2 | 3.00 | 1.00 | 1:4 | 47.31 ± 1.06 | 100.00 ± 1.21 |
| F3 | 3.00 | 2.00 | 1:4 | 56.42 ± 1.11 | 22.46 ± 3.86 |
| F4 | 2.00 | 2.00 | 1:4 | 64.80 ± 0.85 | 37.88 ± 2.78 |
| F5 | 2.00 | 2.00 | 1:3 | 71.58 ± 3.13 | 64.26 ± 1.05 |
| F6 | 2.50 | 1.50 | 1:3.5 | 77.13 ± 0.12 | 97.12 ± 0.89 |
| F7 | 2.50 | 1.50 | 1:3.5 | 80.01 ± 0.54 | 81.29 ± 0.55 |
| F8 | 3.00 | 2.00 | 1:3 | 68.70 ± 1.75 | 9.86 ± 1.75 |
| F9 | 2.50 | 1.50 | 1:3.5 | 75.97 ± 0.70 | 93.65 ± 2.66 |
| F10 | 2.00 | 1.00 | 1:3 | 45.47 ± 1.11 | 100.00 ± 4.58 |
| F11 | 3.00 | 1.00 | 1:3 | 70.63 ± 2.48 | 93.50 ± 3.87 |
| F12 | 2.50 | 1.50 | 1:3.5 | 72.74 ± 0.81 | 94.51 ± 2.99 |