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. 2017 Aug 16;43(1):58–67. doi: 10.1016/j.jgr.2017.08.004

Fig. 5.

Fig. 5

GS-KG9 inhibits the expression of c-Fos in spinal cord dorsal horn in STZ-induced hyperglycemic rats. At 28 d after GS-KG9 (300 mg/kg) administration, lumbar (L4–L5) spinal tissues were prepared and immunostained with a c-Fos antibody. (A) Immunohistochemistry of c-Fos. Right panels are high magnification images (200×). Dotted line indicates c-Fos-positive cells in superficial layer (lamina I, II) of dorsal horn following STZ treatment. (B) Double labeling showed that c-Fos immunoreactivity was colocalized in NeuN-positive neurons (arrows). Scale bars, 30μm. (C) Quantitative analysis of c-Fos-positive cells in lamina I, II (n = 5 rats/group). Data are expressed as the mean ± standard deviation. *p < 0.05 versus STZ control. STZ, streptozotocin.