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. 2018 Nov 2;19:75–85. doi: 10.1016/j.molmet.2018.10.010

Figure 3.

Figure 3

Impaired leptin-induced thermogenesis in CPT1C KO mice. (A–C) Quantification of interscapular temperature changes adjacent to the BAT depot (iBAT) after ICV leptin treatment in WT (A) and CPT1C KO mice (B) compared with ICV vehicle. (C) Area under the curve (AUC) of iBAT temperature during 220 min. (D) Gene expression analysis of thermogenic markers in BAT of WT and KO mice after ICV leptin. Data are expressed as mean ± SEM (n = 5–8). #P < 0.05, ##P < 0.01 versus Vehicle within the same genotype.