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. 2018 Dec 14;19(2):1203–1209. doi: 10.3892/mmr.2018.9765

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Copyright: © Zhang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 2. — Metformin suppresses the EMT process in HCT116 colorectal cancer cells. (A) mRNA and (B) protein levels of EMT markers (E-cadherin and Vimentin) were detected in HCT116 colorectal cancer cells treated with different concentrations of metformin. (C) mRNA and (D) protein levels of EMT markers (E-cadherin and Vimentin) were detected in HCT116 colorectal cancer sphere cells treated with treatment of different concentrations of metformin. Data are presented as the mean ± standard deviation, *P<0.05 and **P<0.01 vs. control. EMT, epithelial-mesenchymal transition.