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. 2018 Dec 14;19(2):1203–1209. doi: 10.3892/mmr.2018.9765

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Copyright: © Zhang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — Reactivation of Wnt3a/β-catenin signaling rescues the metformin-mediated inhibition of stemness and EMT of HCT116 colorectal cancer cells. The potential of HCT116 colorectal cancer cells to form spheroids was detected in HCT116 colorectal cancer cells with Wnt3a overexpression or treatment with SKL2001, with or without metformin treatment, via measuring sphere (A) size and (B) number. (C) mRNA and (D) protein levels of EMT markers (E-cadherin and Vimentin) were determined in the cells in the different treatment groups. Data are presented as the mean ± standard deviation, **P<0.01 vs. control. EMT, epithelial-mesenchymal transition.