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. 2018 Dec 14;19(2):1203–1209. doi: 10.3892/mmr.2018.9765

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Copyright: © Zhang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — Metformin attenuates 5-FU resistance of HCT116 sphere cells. (A) Cell viabilities of HCT116 colorectal cancer cells treated with 5-FU and of HCT116 colorectal cancer sphere cells treated with 5-FU with or without metformin treatment, were determined using a Cell Counting Kit-8 assay. (B) Expression levels of apoptosis executors (cleaved caspase-3 and cleaved PARP) were detected in the cells in the different treatment groups. Data are presented as the mean ± standard deviation; **P<0.01 vs. control. 5-FU, 5-fluorouracil; PARP, poly(ADP-ribose) polymerase.