Table II.
Clinical significance of CCAT1 in various tumours.
| First author, year | Tumour type | Overexpression of lncCCAT1 | Refs. |
|---|---|---|---|
| Nissan, 2012; He, 2014; Jing, 2017; Alaiyan, 2013; Kim, 2014; Ye, 2015; Ozawa, 2017; Zhao, 2015; Kam, 2014; McCleland, 2016 | Colorectal cancer | Clinical stage, lymph nodes metastasis, local infiltration depth, vascular invasion, CA19-9 level, RFS and OS | (22,30,40–46,48) |
| Zhuang, 2016; Zhang, 2017 | Laryngeal squamous cell carcinoma | T3-4 grade, advanced clinical stage | (31,52) |
| Wu, 2016 | Esophageal squamous cell carcinoma | OS, TNM stage, histological grade | (24) |
| Zhang, 2017; Zhang, 2014; Mizrahi I, 2015; Yang, 2013; Zhou B, 2016 | Gastric cancer | Growth of primary tumour, lymph node metastasis, metastatic disease, TNM grade, OS and RFS | (55–59) |
| Deng, 2015; Wang, 2017; Zhu, 2015; Zhu, 2015; Dou, 2017; Dou, 2017 | Hepatocellular carcinoma | Tumour size, Edmondson-Steiner grade, liver cirrhosis, tumour number, prognosis (OS, RFS, disease-free survival), vascular invasion, microvascular invasion, capsular formation, AFP | (25,68–72) |
| Ma, 2015 | Gallbladder cancer | tumour status, lymph node invasion and advanced TNM stage | (75) |
| Jiang, 2017; Zhang, 2017 | Cholangiocarcinoma | Histological differentiation, lymph node invasion, TNM stage, OS | (77,78) |
| Yu, 2016 | Pancreatic cancer | Tumourigenesis, metastasis | (81) |
| White, 2014; Luo, 2014; Cabanski, 2015; Hu, 2017; Lu, 2016; Lu, 2017; Chen, 2016; | Lung cancer | Prognosis biomarker, OS times, TNM stage | (86–92) |
| Cao, 2017; Liu, 2013 | Epithelial ovarian cancer | FIGO stage, histological grade, lymph node metastasis and poor survival | (93,94) |
| Zhang, 2015; Lai, 2017 | Breast cancer | Differentiation grade, TNM stage, and lymph node metastases | (96,97) |
| Jia, 2017 | Cervical cancer | / | (98) |
| Zhao, 2016 | Endometrial carcinoma | FIGO stage, lymph node metastasis, OS | (99) |
| Gao, 2017 | Medulloblastoma | / | (101) |
| Chen, 2016 | Acute myeloid leukemia | / | (102) |
| Zhao, 2017 | Osteosarcoma | / | (103) |
| Wang, 2017 | Nasopharynx cancer | Paclitaxel resistant | (104) |
| Zhang, 2017 | Retinoblastoma | / | (26) |
| Lv, 2017 | Melanoma | / | (105) |
| Wang, 2016; Cui, 2017 | Glioma | Pathological grade | (106,107) |
| Ma, 2017 | HPV-associated head and neck squamous cell carcinoma | Modified tumour inflammation and immunity microenviron ment, myeloid-derived suppressor cell recruitment and cancer development | (100) |
AFP, α-fetoprotein; CCAT1, colon cancer-associated transcript 1; FIGO, Fédération Internationale de Gynécologie et d'Obstétrique; HPV, human papilloma virus; OS, overall survival; RFS, recurrence-free survival; TNM, tumour node metastasis.