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. 2018 Dec 12;19(2):967–973. doi: 10.3892/mmr.2018.9753

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Copyright: © Wang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 1. — Induction of OSKM expression by DOX treatment. B16-F10 mouse melanoma cells, stably-transfected with TetO-FUW-OSKM, were cultured in the presence or absence of DOX. The OSKM mRNA levels were analyzed using reverse transcription-quantitative polymerase chain reaction and normalized to β-actin mRNA. The relative fold activation was obtained based on the ratio of the normalized values of the DOX-induced cells to that of the cells without DOX exposure. *P<0.01 vs. cells without exposure to DOX. OSKM, Oct4, Sox2, Klf4 and c-Myc; DOX, doxycycline.