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. 2018 Dec 4;19(2):831–840. doi: 10.3892/mmr.2018.9723

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Copyright: © Chen et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — REV3L is negatively regulated by miR-29a in non-small cell lung cancer cell lines cells. (A and B) Overexpression of miR-29a decreased REV3L (A) mRNA and (B) protein expression levels in A549 and H1650 cells, as detected by RT-qPCR and western blotting, respectively. (C) mRNA and (D) protein expression levels of REV3L were elevated in A549rCDDP cells in comparison with A549 cells. (E and F) Overexpression of miR-29a decreased REV3L (E) mRNA and (F) protein expression levels in A549rCDDP cells. ***P<0.001. miR, microRNA; NC, negative control; REV3L, REV3-like DNA-directed polymerase ζ catalytic subunit; RT-qPCR, reverse transcription-quantitative polymerase chain reaction.