Fig. 2.

Formal congruence of National Institute of Mental Health RDoC and the Galenic four humors. Depicted: RDoC domains (external labels, in bold), a construct proposed to underlie each domain (base of each triangle), a proposed neurocircuit for the construct (midtriangle), and a neurotransmitter relevant to the neurocircuit (tip of each triangle) [32, 33, 34, 35, 36, 37]. As in the four humors, it is proposed that mental health requires a balance of the factors underlying each domain. Note the congruence of the overall formal structure with that of Figure 1. Other constructs, and different aspects of proposed underlying neurocircuitry, have been hypothesized for each domain, but the specific details do not alter the formal structure - balance across the constructs and circuitry is required for mental health. 5-HT, serotonin; collic., collicular; CRF, corticotropin-releasing factor; DA, dopamine; GABA, gamma-aminobutyric acid; NAc, nucleus accumbens; RDoC, Research Domain Criteria; SCN, suprachiasmatic nucleus; stria term., stria terminalis; VIP, vasoactive intestinal peptide; VTA, ventral tegmental area.