Table 1.

FINDOR Increases Power across 27 UK Biobank Traits

Class	Trait	N	${\mathit{h}}_{\mathit{g}}^{\mathbf{2}}$	145K			459K
				Unweighted	FINDOR	%Improve	Unweighted	FINDOR	%Improve
Anthropometric	balding type I	68K/208K	0.21	96	100	4.2%	334	346	3.6%
	body mass index	145K/458K	0.28	117	132	12.8%	908	950	4.6%
	heel T score	141K/446K	0.33	300	308	2.7%	1,130	1149	1.7%
	height	145K/458K	0.64	674	690	2.4%	2,395	2402	0.3%
	waist-hip ratio	145K/458K	0.17	98	104	6.1%	460	506	10.0%
Blood Cell	eosinophil count	140K/440K	0.21	187	200	7.0%	699	731	4.6%
	mean corpular hemoglobin	141K/443K	0.22	237	248	4.6%	765	791	3.4%
	red blood cell (RBC) count	141K/445K	0.25	192	206	7.3%	840	885	5.4%
	RBC distribution width	141K/445K	0.20	198	212	7.1%	652	674	3.4%
	white blood cell count	131K/444K	0.21	148	165	11.5%	713	750	5.2%
Disease	auto immune traits	145K/459K	0.04	14	18	28.6%	75	86	14.7%
	cardiovascular diseases	145K/459K	0.12	38	49	28.9%	285	314	10.2%
	eczema	145K/459K	0.08	35	46	31.4%	181	198	9.4%
	hypothyroidism	145K/459K	0.05	27	30	11.1%	139	153	10.1%
	respiratory diseases	145K/459K	0.06	24	29	20.8%	104	109	4.8%
	type 2 diabetes	145K/459K	0.05	14	14	0.0%	76	86	13.2%
Other	age at menarche	75K/242K	0.25	52	56	7.7%	318	338	6.3%
	age at menopause	44K/143K	0.11	18	18	0.0%	85	91	7.1%
	FEV1-FVC ratio	124K/370K	0.27	174	185	6.3%	684	714	4.4%
	forced vital capacity (FVC)	124K/372K	0.23	90	99	10.0%	544	565	3.9%
	hair color	143K/452K	0.14	140	143	2.1%	428	436	1.9%
	morning person	130K/410K	0.11	14	14	0.0%	156	165	5.8%
	neuroticism	124K/372K	0.11	11	16	45.5%	128	149	16.4%
	smoking status	145K/458K	0.10	18	24	33.3%	154	178	15.6%
	sunburn occasion	109K/344K	0.07	23	25	8.7%	78	82	5.1%
	systolic blood pressure	134K/422K	0.22	98	106	8.2%	666	703	5.6%
	years of education	144K/455K	0.14	17	24	41.2%	286	315	10.1%
	overall	145K/459K	NA	3,054	3,261	6.8%	13,283	13866	4.4%
	average per-trait	130K/409K	0.18	113	120	13%	491	513	6.9%

For each trait, we report the number of independent, genome-wide significant loci identified by the unweighted approach and by FINDOR in the 145K and 459K UK Biobank releases. Complete results are reported in Table S7.