Figure 2.

Disease-Disease Network

Using the cross-phenotype associations from an EHR-based PheWAS, we generated the disease-disease network (DDN). In this network, nodes represent the diseases, and the edges (lines) between the nodes represent shared genetic associations between pairs of diseases. The color of the node represents the broader disease category to which it belongs. The size of the node indicates the importance of the node in the network; importance was based on the betweenness centrality measure. The bigger nodes have higher betweenness centrality, and these nodes are referred to as hub nodes. The width of the edges (lines) represents the number of shared variants or variants in an LD block.