Table II.

Summary of outcome measures

Outcome measure category (n*)	Primary outcomes	Osteoarthritis and surrogate OA outcomes
Physical examination n = 30	1.Laxity (n = 4) 2.Patellofemoral stability (n = 2) 3.Limb symmetry indices (n = 1) 4.Torque (n = 1) 5.Muscle electrical activity (n = 1) 6.Functional – hop test (n = 1)
Patient reported n = 26	1.Knee injury and Osteoarthritis Outcome Score (KOOS) (n = 5) 2.Hospital for Special Surgery (HSS) knee score (n = 2) 3.International Knee Documentation Committee (IKDC) Subjective Knee Form (n = 2) 4.Kujala score (n = 2) 5.The Knee Self-Efficacy Scale (K-SES) (n = 1) 6.The Physical Activity Scale (n = 1) 7.Tegner activity score (n = 1) 8.Multidimensional Health Locus of Control (n = 1)	1.Knee injury and Osteoarthritis Outcome Score (KOOS) (n = 1)
Imaging n = 43	1.Radiographic: Kellgren–Lawrence classification (n = 1) 2.CT: Quality of reduction (n = 1) 3.MRI: Morphologic measures of articulating bone curvature (femur, tibia & trochlea) (n = 1) 4.MRI: Cartilage thickness of femorotibial medial compartment (n = 1) 5.MRI: Anterior Cruciate Ligament Osteoarthritis Score (ACLOS) (n = 1)	1.Radiographic: Study specified criteria incl. joint space narrowing, osteophyte grade, subchondral sclerosis and sharpening of tibial spines (n = 4) 2.Radiographic: Kellgren–Lawrence classification (n = 4) 3.Radiographic: Ahlbäck classification (n = 2) 4.Radiographic: modified OARSI grading scale for OA (n = 1) 5.Radiographic: Medial joint space width (n = 1) 6.Radiographic: Ahlbäck & Fairbank composite scale (n = 1) 7.MRI: Whole Organ Magnetic Resonance Imaging Score (WORMS) (n = 1) 8.MRI: Anterior Cruciate Ligament Osteoarthritis Score (ACLOAS) (n = 1) 9.qMRI: Early matrix changes typical of arthritis (n = 1)
Biomarkers (n = 39)	1. GAG/proteoglycan marker: ARGS-aggrecan (n = 1)
Other (n = 9)	2. Safety, tolerability & adverse effects (n = 1)
TOTAL n = 147	Total = 21 primary outcomes	Total = 10 measures

*where n = total number of studies with such measures.