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. Author manuscript; available in PMC: 2019 Jan 8.
Published in final edited form as: J Nat Prod. 2016 May 3;79(5):1267–1275. doi: 10.1021/acs.jnatprod.5b00846

Table 3.

Concentrations of Pyrroloiminoquinone Alkaloids Causing Significant Inhibition of Luciferase Activity in COLO 205, HCT 116, and LNCaP Cells (p < 0.05)

compound COLO 205 HCT 116 LNCaP
1 no effect 0.1,0.25,0.5, 1, 10a μM 1, 10a μM
2 no effect 0.1, 0.25, 0.5, 1 μM 1 μM
3 no effect 10 μM 1, 10a μM
5 no effect 0.25, 1 μM 0.1, 1, 10 μM
8 no effect 0.5, 1 μM 0.1 μM
9 no effect 0.1, 0.25, 0.5, 1, 10a μM 1, 10a μM
11 no effect 0.1, 0.25,0.5, 1, 10 μM no effect
a

>50% cell death in CCK-8 assay.