Table 3.
Ranking of the top 10 upregulated and downregulated differentially expressed genes in the poly(I:C) dataset. Ranking based on fold change
| Gene | ID | Name | Fold change | p value | FDR |
|---|---|---|---|---|---|
| A | |||||
| TNFSF10 | 507,215 | tumor necrosis factor superfamily member 10, transcript variant X1 | 3838.1 | 1.5 × 10−17 | 4.1 × 10− 15 |
| IFIT2 | 527,528 | interferon induced protein with tetratricopeptide repeats 2 | 2354.2 | 7.8 × 10− 16 | 1.5 × 10− 13 |
| RSAD2 | 506,415 | radical S-adenosyl methionine domain containing 2 | 2258.9 | 1.9 × 10−28 | 5.2 × 10− 25 |
| IFI44L | 508,347 | interferon induced protein 44 like | 2010.7 | 2.8 × 10−15 | 4.8 × 10− 13 |
| OAS1a | 347,699 | 2′,5′-oligoadenylate synthetase 1, 40/46 kDa | 1591.7 | 9.7 × 10− 23 | 5.3 × 10− 20 |
| IFI44 | 508,348 | interferon induced protein 44, transcript variant X1 | 1254.3 | 1.8 × 10− 13 | 2.6 × 10− 11 |
| ISG15 | 281,871 | ISG15 ubiquitin-like modifier | 1033.6 | 4.9 × 10−30 | 1.6 × 10−26 |
| MX1 | 280,872 | MX dynamin-like GTPase 1, transcript variant X2 | 967.8 | 1.8 × 10−27 | 3.6 × 10− 24 |
| MX2 | 280,873 | MX dynamin-like GTPase 2, transcript variant X1 | 895.4 | 4.0 × 10− 20 | 1.4 × 10−17 |
| OAS2 | 529,660 | 2′-5′-oligoadenylate synthetase 2 | 807.5 | 8.7 × 10− 12 | 9.9 × 10− 10 |
| B | |||||
| CYP1A1 | 282,870 | cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 1, transcript variant X2 | −3.8 | 8.1 × 10− 12 | 9.3 × 10− 10 |
| EXOC3L2 | 539,328 | exocyst complex component 3-like 2 | − 3.7 | 1.2 × 10− 4 | 3.3 × 10− 3 |
| USH1G | 531,104 | Usher syndrome 1G (autosomal recessive) | − 3.3 | 1.3 × 10− 3 | 2.1 × 10− 2 |
| CYP26B1 | 540,868 | cytochrome P450, family 26, subfamily B, polypeptide 1 | − 3.1 | 1.9 × 10− 3 | 2.8 × 10− 2 |
| SMIM17 | 100,849,034 | small integral membrane protein 17, transcript variant X4 | − 2.9 | 1.5 × 10− 3 | 2.3 × 10− 2 |
| DAAM2 | 783,665 | dishevelled associated activator of morphogenesis 2, transcript variant X1 | − 2.8 | 1.1 × 10− 3 | 1.9 × 10− 2 |
| TMEM52 | 617,403 | transmembrane protein 52 | − 2.7 | 3.5 × 10− 3 | 4.4 × 10− 2 |
| CYP1B1 | 511,470 | cytochrome P450, family 1, subfamily B, polypeptide 1 | − 2.6 | 6.8 × 10− 11 | 6.9 × 10− 9 |
| WASF3 | 540,674 | WAS protein family member 3, transcript variant X4 | −2.3 | 2.7 × 10− 3 | 3.1 × 10− 2 |
| ATOH8 | 616,225 | atonal bHLH transcription factor 8, transcript variant X1 | − 2.2 | 9.5 × 10− 10 | 8.2 × 10− 8 |
(A) upregulated, (B) downregulated. Data were analyzed in IPA (QIAGEN Inc., https://www.qiagenbioinformatics.com/products/ingenuity-pathway-analysis