Table 3.
Efficacy of systemic therapies against generalised demodicosis in dogs. References 9 and 22 are repeated twice because two different protocols were tested in the same study
| Reference | Therapy | Posology | Adverse effects | Treatment duration | Efficacy |
|---|---|---|---|---|---|
| [5] | MILBEMYCIN OXIME | 1–2 mg/kg per os every 24 h. | not reported | 2 | 3 |
| [6] | IVERMECTIN | 0.6 mg/kg per os every 24 h. | 2 | 2 | 3 |
| [7] | MILBEMYCINE OXIME | 0.5–1.6 mg/kg per os every 24 h. | 3 | 2 | 3 |
| [8] | MILBEMYCIN OXIME | 0.5–1 mg/kg or 1–2 mg/kg every 24 h. for 4 weeks. | 1 | 2 | 3 |
| [9] | IVERMECTIN tablets | 0.6 mg/kg per os every 24 h. | 1 | 1 | 3 |
| [9] | MOXIDECTIN | 0.5 mg/kg per os every 72 h. | 1 | 1 | 3 |
| [12] | DORAMECTIN | 0.6 mg/kg per os weekly. | 2 | 2 | 2 |
| [13] | MOXIDECTIN | 0.4 mg/kg per os every 24 h. | 1 | 2 | 3 |
| [16] | IVERMECTIN | 0.5 mg/kg per os every 24 h. | 3 | 2 | 3 |
| [17] | IVERMECTIN | 0.5 mg/kg per os every 24 h. | 1 | 1 | 3 |
| [18] | FLURALANER | 25 mg/kg per os once. | 3 | 2 | 3 |
| [19] | SAROLANER | 2 mg/kg per os every 30 days for 3 times. | 3 | 2 | 3 |
| [20] | AFOXOLANER | 2.5 mg/kg per os every 2 weeks for 4 times. | 3 | 2 | 3 |
| [21] | LOTILANER | 20 mg/kg per os monthly for 3 times. | 3 | 2 | 3 |
| [22] | DORAMECTIN | 600 μg/kg s.c. once a week | 3 | 2 | 3 |
| [22] | DORAMECTIN | 600 μg/kg per os twice a week | 3 | 2 | 3 |
| [23] | SAROLANER | 2–4 mg/kg per os every 30 days | 3 | 2 | 3 |
| [24] | FLURALANER | 25–50 mg/kg per os once or every 12 weeks | 3 | 2 | 3 |