Table 1.
The genotype distribution and H-W of XRCC1 (rs25487), TP53 (rs1042522) and FGFR3 (rs121913483)
| Variable | Alleles | Phenotype | N | HWE | MAF | M/M (%) | M/m (%) | m/m (%) | M/M +M/m | M/m +m/m | Allele M | Allele m |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| rs25487 | G > A | Cases | 121 | 0.18 | 0.40 | 47(38.9) | 51(42.1) | 23(19) | 98 | 74 | 145(59.9) | 97(40.1) |
| NC | 118 | 0.15 | 0.25 | 70(59.3) | 38(32.2) | 10(8.5) | 108 | 48 | 178(75.4) | 58(24.6) | ||
| OC | 101 | 0.45 | 0.27 | 55(54.4) | 37(36.6) | 9(9) | 92 | 46 | 147(72.8) | 55(27.2) | ||
| rs1042522 | G > C | Cases | 121 | 0.18 | 0.38 | 50(41.3) | 50(41.3) | 21(17.4) | 100 | 71 | 150(62) | 92(38) |
| NC | 108 | 0.74 | 0.42 | 37(34.3) | 51(47.2) | 20(18.5) | 88 | 71 | 125(57.9) | 91(42.1) | ||
| OC | 99a | 0.07 | 0.44 | 35(35.4) | 40(40.4) | 24(24.2) | 75 | 64 | 110(55.6) | 88(44.4) | ||
| rs121913483 | G > C | Cases | 117 | 117 | 0 | 0 | ||||||
| NC | 113 | 113 | 0 | 0 | ||||||||
| OC | 89 | 89 | 0 | 0 |
N Number, HWE Hardy-Weinberg equilibrium, MAF Minor allele frequency, NC Negative controls, OC Old controls
aThe number of subjects in each group at different sites may be different due to insufficient DNA