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. 2019 Jan 8;38:9. doi: 10.1186/s13046-018-0990-1

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — The expressions of MOV10 in GECs and knockdown of MOV10 suppressed the viability, migration and tube formation of GECs in vitro and MOV10 combined with circ-DICER1 and regulated its expression. a-b The mRNA and protein expressions of MOV10 in AECs and GECs were evaluated by qRT-PCR and western blot. GAPDH was used as an endogenous control. IDVs represents “Integrated Density Values”. Data represent means ± SD (n = 5, each group). **P < 0.01 vs. AECs group. c Effects of MOV10 knockdown on cell viability of GECs were detected by CCK-8 assay. Data are presented as the means ± SD (n = 5, each group). **P < 0.01 vs MOV10 (−) NC group. d Effects of MOV10 knockdown on migration of GECs were detected by Transwell assay. Data are presented as the means ± SD (n = 5, each group). **P < 0.01 vs MOV10 (−) NC group. Scale bar represents 30 μm. e Effects of MOV10 knockdown on tube formation of GECs were measured by Matrigel tube formation assay. Data are presented as the means ± SD (n = 5, each group). **P < 0.01 vs MOV10 (−) NC group. Scale bar represents 30 μm. f Effects of MOV10 knockdown on expression of circ-DICER1 were detected by qRT-PCR. Data are presented as the means ± SD (n = 5, each group). **P < 0.01 vs MOV10 (−) NC group. g Relative enrichment of circ-DICER1 in anti-IgG and anti-MOV10 were detected by RNA immunoprecipitation assay. Data represent means ± SD (n = 3, each group). **P < 0.01 vs. anti-IgG group