Table 3.

Practical Advice for Clinical Management

- Consult dermatology and biopsy right away, photographs recommended to help document rash.

- Consider obtaining CRP as surrogate for IL-6 as patients may present with SIRS.

- Consider re-initiation of therapy after rash (at lower dose, with steroid overlap), particularly if no signs of SJS, biopsy appears benign relative to clinical rash, and patient was having a good response to the therapy or does not have alternate therapy options.

- Consider avoidance of other stimulating medications or known activating medications such as amoxicillin, amoxicillin-clavulanic acid, allopurinol