Table 3.
Protein-protein interaction (PPI) retention annotation of KMT2A-MLLT10 fusion protein from FusionGDB
| A. Protein–protein interactors with each partner protein of wild type from BIOGRID-3.4.160 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Hgene | Hgene's interactors | Tgene | Tgene's interactors | |||||||
| KMT2A | PPIE, PPP1R15A, KMT2A, ASH2L, HCFC1, HCFC2, MEN1, RBBP5, WDR5, AVP, INS, OXT, MAP3K5, HDAC1, CTBP1, CBX4, BMI1, CREBBP, SMARCB1, CXXC1, MYB, CTNNB1, SNW1, E2F2, E2F4, E2F6, PSIP1, MLLT4, POLR2A, KAT8, RNF2, TP53, SBF1, MTM1, SET, HIST1H3A, HIST1H4A, KAT6A, ELL, AFF1, AFF4, CDK9, CCNT1, CTR9, LEO1, PAF1, CDC73, WDR61, MLLT3, DOT1L, SKP2, HIST3H3, SVIL, HIST2H3C, SIN3A, MLLT1, RUNX1, CBFB, H3F3A, SIRT7, ASB2, TCEB1, TCEB2, CBX8, TOP1, TAF6, NCL, HECW2, LGR4, CSNK2A2, SENP3, SYMPK, PKN1, PIH1D1, KRAS, TAF1, CHD3, SMARCA2, SMARCC2, SMARCC1, HDAC2, RBBP4, RBBP7, TBP, MBD3, SAP30, RAN, TAF9, TASP1, HIST1H2BG, EWSR1, DYNLT1, KIF11, ING4, ZNF131, ASB7 | MLLT10 | YEATS4, SMARCB1, SS18, MLLT10, DOT1L, MLLT1, MLLT3, AFF1, DISC1, NDEL1, ELAVL1, CENPJ, TMPO, ZNF526, MLLT6, TCP10L, KIF6, PMF1 | |||||||
| B. Still kept PPIs in the in-frame KMT2A-MLLT10 fusion protein with retention. | ||||||||||
| Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Still interaction with |
| MLLT10 | chr11:118352807 | chr10:22002700 | ENST00000377091 | + | 0 | 5 | 141_233 | −59 | 127 | FSTL3 |
| MLLT10 | chr11:118352807 | chr10:22002700 | ENST00000377100 | + | 0 | 4 | 141_233 | −119 | 180 | FSTL3 |
| MLLT10 | chr11:118355029 | chr10:21959377 | ENST00000377091 | + | 0 | 5 | 141_233 | −59 | 127 | FSTL3 |
| MLLT10 | chr11:118355029 | chr10:21959377 | ENST00000377100 | + | 0 | 4 | 141_233 | −119 | 180 | FSTL3 |
| MLLT10 | chr11:118355690 | chr10:21959377 | ENST00000377091 | + | 0 | 5 | 141_233 | −59 | 127 | FSTL3 |
| MLLT10 | chr11:118355690 | chr10:21959377 | ENST00000377100 | + | 0 | 4 | 141_233 | −119 | 180 | FSTL3 |
| C. Lost PPIs in the in-frame KMT2A-MLLT10 fusion protein without retention. | ||||||||||
| Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Interaction lost with |
| KMT2A | chr11:118352807 | chr10:22002700 | ENST00000354520 | + | 7 | 35 | 1584_1600 | 1337 | 3932 | histone H3K4me3 |
| KMT2A | chr11:118352807 | chr10:22002700 | ENST00000389506 | + | 7 | 36 | 1584_1600 | 1337 | 3970 | histone H3K4me3 |
| KMT2A | chr11:118352807 | chr10:22002700 | ENST00000534358 | + | 7 | 36 | 1584_1600 | 1337 | 3973 | histone H3K4me3 |
| KMT2A | chr11:118355029 | chr10:21959377 | ENST00000354520 | + | 9 | 35 | 1584_1600 | 1406 | 3932 | histone H3K4me3 |
| KMT2A | chr11:118355029 | chr10:21959377 | ENST00000389506 | + | 9 | 36 | 1584_1600 | 1406 | 3970 | histone H3K4me3 |
| KMT2A | chr11:118355029 | chr10:21959377 | ENST00000534358 | + | 9 | 36 | 1584_1600 | 1406 | 3973 | histone H3K4me3 |
| KMT2A | chr11:118355690 | chr10:21959377 | ENST00000354520 | + | 1 | 35 | 1584_1600 | 0 | 3932 | histone H3K4me3 |
| KMT2A | chr11:118355690 | chr10:21959377 | ENST00000389506 | + | 10 | 36 | 1584_1600 | 1444 | 3970 | histone H3K4me3 |
| KMT2A | chr11:118355690 | chr10:21959377 | ENST00000534358 | + | 10 | 36 | 1584_1600 | 1444 | 3973 | histone H3K4me3 |
| KMT2A | chr11:118352807 | chr10:22002700 | ENST00000354520 | + | 7 | 35 | 3764_3771 | 1337 | 3932 | WDR5 |
| KMT2A | chr11:118352807 | chr10:22002700 | ENST00000389506 | + | 7 | 36 | 3764_3771 | 1337 | 3970 | WDR5 |
| KMT2A | chr11:118352807 | chr10:22002700 | ENST00000534358 | + | 7 | 36 | 3764_3771 | 1337 | 3973 | WDR5 |
| KMT2A | chr11:118355029 | chr10:21959377 | ENST00000354520 | + | 9 | 35 | 3764_3771 | 1406 | 3932 | WDR5 |
| KMT2A | chr11:118355029 | chr10:21959377 | ENST00000389506 | + | 9 | 36 | 3764_3771 | 1406 | 3970 | WDR5 |
| KMT2A | chr11:118355029 | chr10:21959377 | ENST00000534358 | + | 9 | 36 | 3764_3771 | 1406 | 3973 | WDR5 |
| KMT2A | chr11:118355690 | chr10:21959377 | ENST00000354520 | + | 1 | 35 | 3764_3771 | 0 | 3932 | WDR5 |
| KMT2A | chr11:118355690 | chr10:21959377 | ENST00000389506 | + | 10 | 36 | 3764_3771 | 1444 | 3970 | WDR5 |
| KMT2A | chr11:118355690 | chr10:21959377 | ENST00000534358 | + | 10 | 36 | 3764_3771 | 1444 | 3973 | WDR5 |
| MLLT10 | chr11:118352807 | chr10:22002700 | ENST00000307729 | + | 12 | 23 | 141_233 | 566 | 1069 | FSTL3 |
| MLLT10 | chr11:118352807 | chr10:22002700 | ENST00000377072 | + | 13 | 24 | 141_233 | 582 | 1476 | FSTL3 |
| MLLT10 | chr11:118355029 | chr10:21959377 | ENST00000307729 | + | 8 | 23 | 141_233 | 265 | 1069 | FSTL3 |
| MLLT10 | chr11:118355029 | chr10:21959377 | ENST00000377072 | + | 8 | 24 | 141_233 | 265 | 1476 | FSTL3 |
| MLLT10 | chr11:118355690 | chr10:21959377 | ENST00000307729 | + | 8 | 23 | 141_233 | 265 | 1069 | FSTL3 |
| MLLT10 | chr11:118355690 | chr10:21959377 | ENST00000377072 | + | 8 | 24 | 141_233 | 265 | 1476 | FSTL3 |