Figure 3.

Integrative viewing of translation activity of a target gene (ADAM17) and its post-transcriptionally regulation events. (A) In the ‘Translatome’ module, all ORFs in ADAM17 are summarized based on their categories (i). Users can investigate each ORF by clicking on the name of the ORF (ii). For example, in ADAM17, estimation on the translation efficiency (iii) and the signal track (iv) reveals the potential of translation up-regulation in tumor samples compared to normal. (B) In the RBP module, search on ADAM17 provides the interactions network of ADAM17 gene and various RBPs (v). The number of RBPs binding along the transcript (vi) and genomic context of the binding sites (vii) can be visualized and searched. At last, the impact of SNVs in RBP-binding sites in both TCGA (viii) and COSMIC (ix) datasets further supports the association between ADAM17 and tumorigenesis.