Figure 2.

BitterDB possible usage: Panel 1+2: Compounds advanced search was chosen from menu, in mouse mode. Panel 3: In advanced search page, the options for compounds with specific data on rat acute oral LD₅₀ and data on associated receptors were chosen. Panel 4: Search result panel, 14 compounds that fit the criteria were found, caffeine was selected for detailed view. Panel 5: Caffeine page in BitterDB: (A) Detailed description of the resources about caffeine bitterness and description of specific bitter taste when available. (B) Detailed data, including receptor activation measures from in vitro studies of associated receptor in mice (when moving to ‘All species’ mode, more targets will be shown). (C) Quantitative sensory data: detailed information about the sensory bitter recognition thresholds from three different publications is represented. (D) The toxicity measure (rat acute LD₅₀) can be found in the compound properties.