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. 2018 Nov 24;47(Database issue):D529–D541. doi: 10.1093/nar/gky1079

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© The Author(s) 2018. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 2. — Example of result summary page for chemical interactions of the E3 ubiquitin ligase VHL. (A) Details for Bivalent_ligand_52, a PROTAC composed of a ligand for VHL and a ligand for the degradation targets EFGR and ERBB2 (68). (B) Additional notes display the BVL name in a standardized format based on details provided in the original paper. (C) Chemical-protein interactions curated by BioGRID also include other small molecule inhibitors of UPS enzymes, in this case VH298 as an inhibitor of VHL. External links to ChemSpider provide additional chemical information.