FIG. 1.

Predictions by the full constrained mixture model (first case, dashed; second case, dash-dotted) for the evolution of (c) medial and adventitial collagen (referential) mass density, (d) inner radius, (e) medial thickness, and (f) adventitial thickness, each normalized to original values, which result from two different cases of perturbations in loading [(a), solid lines] that cause (b) evolving stimulus functions (i.e., stresses different from homeostatic target values). Panels (g)–(i) show, separately, associated deviations in stress components from original homeostatic values. Note the two different time-delayed combinations of changes in pressure and flow (a). Shown, too, is the long-term, mechanobiologically equilibrated solution (solid square), which is the same for each of the two (same final) loading conditions. Note the perfect correspondence of the long-term steady-state solution computed with the present time-independent formulation and the full (hereditary) constrained mixture model.