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. 2018 Aug 7;2(3):031907. doi: 10.1063/1.5024744

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© 2018 Author(s).

2473-2877/2018/2(3)/031907/19

All article content, except where otherwise noted, is licensed under a Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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FIG. 1. — Schematic of the mechanism of metastasis and the experimental design. (a) Stromal cells and cancer cells form hybrids spontaneously in vivo; such hybrids contribute to metastatic mass. The hybrids are well-equipped to migrate out of the primary tumor and reestablish themselves at secondary sites. (b) Scheme to evaluate the metastatic potential of tumor-stroma hybrids in vitro. (c) Scheme to evaluate the metastatic potential of tumor-stroma cell hybrids in vivo.