FIG. 8.

Assessment of the tumor invasive morphology and time to endpoint. (a) Tumors were removed from mice and stained with hematoxylin and eosin. All tumors showed signs of invasiveness whether or not visible metastases were detected in the lung. Muscle is labeled with a white M. Slide scan: scale bar 1000 μm. 20× inset: scale bar 50 μm. (b) Average time to maximum primary tumor size (2 cm) was lower in co-culture (Co) injected mice relative to PyVT injected mice. PyVT, Cre_PyVT; Co, Cre_PyVT-FloxLuc_mMSC co-culture cells that included fusion products.