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. 2018 Jun 8;2(3):032001. doi: 10.1063/1.5019770

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© 2018 Author(s).

2473-2877/2018/2(3)/032001/12

All article content, except where otherwise noted, is licensed under a Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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FIG. 5. — Migration of cancer cells in a microfluidic device. (a) Proportion of cells exhibiting PI uptake while entering or migrating across channels for different channel widths (the number of cells are denoted in parenthesis; error bars denote the standard error of proportion). (b) Average velocity of MDA-MB-231 no MscL and MDA-MB-231 MscL G22S cells in different sized channels of the microfluidic device. Circles represent the average migration of individual cells; black bars are the average velocity for all cells for the given channel width. 2-way ANOVA shows that the interaction between the cell type and the channel width is not significant, and so, the effect on cell migration in different channel widths does not depend on MscL expression. (c) Box plots of average cell migration for no MscL and MscL G22S cells in the confined channels. (d) Example of time-lapse fluorescence images of an MDA-MB-231 MscL G22S cell that migrated (left) or was stuck (right) in 3 μm channels. The scale bar is 10 μm. (e) Fractions of stuck MDA-MB-231 cells without and with MscL G22S. Error bars represent the standard error of proportion. The total number of cells is denoted in parenthesis. *p < 0.05.