Fig. 2.

(A) Longitudinal changes in LMCI stratified by sex and amyloid positivity. The dotted lines represent women, and the solid lines represent men. (B) Longitudinal changes in LMCI stratified by APOE ε4 allele status. (C) Longitudinal changes in LMCI and AD stratified by CKD grade. The solid lines represent CKD grade G1 and the dotted lines represent CKD grade ≥ G2. (D) Kaplan-Meyer plot of MCI to AD conversion stratified by sex, educational level, and CKD grades. Statistically significant differences were assessed using the log-rank test for sex and education; the log-rank test showed a trend toward significance for education level. The overall conversion rate is shown below the graphs. Abbreviations: LMCI, late mild cognitive impairment; AD, Alzheimer's disease; CKD, chronic kidney disease; APOE, apolipoprotein E.