Table 2. Independent Risk Factors for Delirium From NICE-Based Prediction Rules.
| Risk Factor for Delirium | NICE Meta-analysis21 Odds Ratio (95% CI) | Prediction Rule Weights | ||
|---|---|---|---|---|
| eNICE | Pendlebury NICE | Consolidated NICE | ||
| Cognitive impairment | 6.3 (2.9-13.7) | 4 | 2 | 3 |
| Age ≥65 y | 3.0 (1.2-7.7) | 2 | NA | NA |
| Age ≥80 y | 5.2 (2.6-10.4) | 3 | 2 | 1 |
| Infection | 3.0 (1.4-6.1) | 2 | 1 | 1 |
| Fracture | 6.6 (2.2-19.3) | 4 | NA | NA |
| Visual impairment | 1.7 (1.0-2.8) | 1 | 1 | NA |
| Severe illness | 3.5 (1.5-8.2) | NA | NA | NA |
| Acute physiology score | NA | 2 | NA | NA |
| SIRS criteriaa | NA | NA | 1 | NA |
| Serum sodium level | NA | NA | NA | 1 |
Abbreviations: eNICE, electronic National Institute for Health and Care Excellence; NA, not applicable; NICE, National Institute for Health and Care Excellence; SIRS, systematic inflammatory response syndrome.
a
SIRS was noted as positive if at least 2 of the following were present: heart rate greater than 90 beats/min, respiratory rate greater than 20 breaths/min, and white blood cell count less than 4000/μL or greater than 12 000/μL (to convert to ×109/L, multiply by 0.001). Temperature was not available in our data sets and therefore was excluded from SIRS calculations.