. 2018 Jul 20;1(3):e180756. doi: 10.1001/jamanetworkopen.2018.0756

Table 2. Primary, Secondary, and Exploratory Outcomes From Baseline to 12 Months for Intermittent vs Continuous Groups (Intention-to-Treat Analysis)^a.

Variable	Mean (SEM) [95% CI]	P Value for Time	Mean (SEM) [95% CI]		P Value for Diet by Time
Variable	Mean (SEM) [95% CI]	P Value for Time	Continuous Restriction Group	Intermittent Restriction Group	P Value for Diet by Time
Primary outcome
HbA_1c, %	−0.4 (0.1) [−0.6 to −0.2]	<.001	−0.5 (0.2) [−0.8 to −0.2]	−0.3 (0.1) [−0.6 to −0.08]	.65
Secondary outcomes
Weight, kg	−5.9 (0.6) [−7.1 to −4.8]	<.001	−5.0 (0.8) [−6.6 to −3.5]	−6.8 (0.8) [−8.5 to −5.1]	.25
BMI	−2.1 (0.2) [−2.5 to −1.7]	<.001	−1.9 (0.3) [−2.4 to −1.3]	−2.3 (0.3) [−2.9 to −1.7]	.43
Total body fat, %^b	−1.8 (0.4) [−2.5 to −1.1]	<.001	−1.6 (0.3) [−2.2 to −0.9]	−2.3 (0.6) [−3.5 to −1.1]	.20
Total fat mass, kg^b	−4.1 (0.5) [−5.0 to −3.2]	<.001	−3.4 (0.6) [−4.6 to −2.2]	−4.7 (0.7) [−6.1 to −3.4]	.20
Total fat-free mass, kg^b	−1.8 (0.3) [−2.4 to −1.3]	<.001	−1.6 (0.4) [−2.3 to −0.8]	−2.1 (0.4) [−2.9 to −1.4]	.11
Android fat, %^b^,^c	−3.8 (1.1) [−5.9 to −1.7]	<.001	−2.0 (1.2) [−4.4 to −0.5]	−5.6 (1.7) [−9.0 to −2.1]	.23
Android fat mass, kg^b	−0.8 (0.2) [−1.2 to −0.5]	<.001	−0.6 (0.2) [−1.1 to −0.2]	−1.1 (0.2) [−1.5 to −0.6]	.37
Android fat-free mass, kg^b	−0.3 (0.1) [−0.5 to −0.04]	.05	−0.3 (0.2) [−0.6 to −0.02]	−0.3 (0.2) [−0.6 to −0.08]	.75
VAT, kg^b	−0.2 (0.06) [−0.3 to −0.1]	<.001	−0.2 (0.09) [−0.4 to −0.02]	−0.2 (0.09) [−0.4 to −0.08]	.42

Abbreviations: BMI, body mass index (calculated as weight in kilograms divided by height in meters squared); HbA_1c, hemoglobin A_1c; VAT, visceral adipose tissue.

SI conversion factor: To convert HbA_1c to proportion of total hemoglobin, multiply by 0.01.

^{^a}

Data were included for 137 participants (67 in the continuous energy restriction group and 70 in the intermittent energy restriction group) unless otherwise stated: mean (SEM) and 95% CI were estimated using an intention-to-treat analysis with a linear mixed model.

^{^b}

For a total of 128 participants (64 in the continuous energy restriction group and 64 in the intermittent energy restriction group) with weight greater than 130 kg or who declined dual-energy x-ray absorptiometry scan.

^{^c}

Percentage fat of tissue in the android region.

Table 2. Primary, Secondary, and Exploratory Outcomes From Baseline to 12 Months for Intermittent vs Continuous Groups (Intention-to-Treat Analysis)a.

Table 2. Primary, Secondary, and Exploratory Outcomes From Baseline to 12 Months for Intermittent vs Continuous Groups (Intention-to-Treat Analysis)^a.