Table 1. Data Sources.
| Data Source | Years Included | Purpose | Individuals Represented, No. | Cases, No. | Data Extraction Notes |
|---|---|---|---|---|---|
| NHANES | 1999-2016 | National HCV RNA prevalence overall and by strata of sex, race/ethnicity, birth cohort, and poverty; trends in HCV antibody inform analysis weights | 47 387 With nonmissing HCV RNA test results; 47 590 with nonmissing HCV antibody test resultsa | 575 With positive HCV RNA test; 874 with positive HCV antibody testa | NHANES 2000, 2002, 2004, 2006, 2008, 2010, 2012, 2014, 2016 data sets |
| US Census intercensal data | 1999-2016 | Population structure for modeling HCV- and overdose-related mortality rates | 4 109 869 228 Person-years aged ≥18 y | NA | US Vintage 2000, Vintage 2009, Vintage 2016 data sets |
| US Census American Community Survey | 2012-2016 | Noninstitutionalized US population structure for final estimates | 12 023 450 Observations of noninstitutionalized persons aged ≥18 y | NA | 5-y Public Use Microdata Sample |
| National Vital Statistics System | 1999-2016 | Distribution of hepatitis C–related mortality, signaling underlying HCV prevalence, to inform distribution of older HCV infections | 44 071 310 Decedents aged ≥18 y who resided in the 50 states or the District of Columbia | 261 858 With HCV as underlying or multiple cause of death | ICD-10 codes included acute viral hepatitis C (B17.1) and chronic viral hepatitis C (B18.2) |
| National Vital Statistics System | 1999-2016 | Distribution of narcotic overdose mortality, signaling underlying injection patterns, to inform distribution of newer HCV infections | 44 071 310 Decedents aged ≥18 y who resided in the 50 states or the District of Columbia | 541 130 With unintentional or undetermined cause narcotic or unknown drug as underlying or multiple cause of death | ICD-10 codes included poisoning by and exposure to narcotics and psychodysleptics (hallucinogens) (X42 unintentional, Y12 undetermined intent); poisoning by and exposure to other and unspecified drugs, medicaments, and biological substances (X44 unintentional, Y14 undetermined intent) |
Abbreviations: HCV, hepatitis C virus; ICD-10, International Classification of Diseases, Tenth Revision; NA, not applicable; NHANES, National Health and Nutrition Examination Survey.
a
Hepatitis C virus antibody screening test data are included for all years. Confirmatory test data for HCV antibodies are not publicly available for 2015 to 2016.