Figure 3. Major Adverse Limb Events and Safety Events According to Polyvascular Disease Phenotype .

Adjusted rates presented as events per 100 patient-years. Reference group was patients with peripheral artery disease (PAD) alone. Acute limb ischemia was adjusted for baseline ankle-brachial index (ABI), randomized treatment, inclusion criteria, use of statins before randomization, and use of angiotensin receptor blockers before randomization. Lower-extremity revascularization was adjusted for baseline ABI, estimated glomerular filtration rate, inclusion criteria, diabetes (type 1 or 2), use of aspirin before randomization, use of clopidogrel before randomization, and smoking status. Amputation was adjusted for weight, baseline ABI, inclusion criteria, critical limb ischemia, diabetes, use of statins before randomization, prior major amputation, and prior minor amputation. Major bleeding was adjusted for age, randomized treatment, and geographic region. Minor bleeding was adjusted for age, baseline ABI, inclusion criteria, sex, randomized treatment, and geographic region. CAD indicates coronary artery disease; CVD, cerebrovascular disease; HR, hazard ratio; and TIMI, Thrombolysis in Myocardial Infarction.